Methanofuran-b is required for CO2formation from formaldehyde byMethanosarcina barkeri

VISA Is Required for B Cell Expression

Rab11 is required for maintenance of cell shape via βPS integrin mediated cell adhesion in Drosophila

In eukaryotes, vesicle trafficking is regulated by the small monomeric GTPases of the Rab protein family. Rab11, (a subfamily of the Ypt/Rab gene family) an evolutionarily conserved, ubiquitously expressed subfamily of small monomeric Rab GTPases, has been implicated in regulating vesicular trafficking through the recycling of endosomal compartment. In an earlier communication, we have shown th...

How Much Time is Required for the Process of Reviewing and Publishing an Article?

از زمانی که پژوهش‌گران نگارش یک مقاله را به پایان برده و ارسال آن به مجله را در دستور کار خویش قرار می‌دهند، یکی از مهم‌ترین سؤالاتی که ممکن است ذهن آن‌ها را مشغول نماید این است که: " در مجله مورد نظر، چقدر زمان برای فرآیند بررسی و چاپ یک مقاله مورد نیاز است؟" این سوال، به خصوص برای دانشجویان تحصیلات تکمیلی که برای چاپ مقاله خود عجله دارند، از اهمیت بیش‌تری برخوردار است. توصیه شخصی من این است...

Aryl hydrocarbon receptor is required for optimal B‐cell proliferation

The aryl hydrocarbon receptor (AhR), a transcription factor known for mediating xenobiotic toxicity, is expressed in B cells, which are known targets for environmental pollutants. However, it is unclear what the physiological functions of AhR in B cells are. We show here that expression of Ahr in B cells is up-regulated upon B-cell receptor (BCR) engagement and IL-4 treatment. Addition of a nat...

VISA is required for B cell expression of TLR7.

B cells play a critical role in the initialization and development of the systemic lupus erythematosus that is dependent on the expression of the endosomal ssRNA receptor TLR7. Previous studies have established that B cell expression of TLR7 is controlled by the type I IFN secreted by plasmacytoid dendritic cells. In this article, we report that VISA, also known as MAVS, IPS-1, and CardIf, esse...